Hi MCK,
1) Legible? Yes. Comfortable? Not really. I wouldn't even try to play the game without the fullscreen option. Opera, 1920x1080, 24"
2) Yes, but without knowing Spanish it is a lot about guessing what different types of towers do. Also I didn't notice any chests. I always lost after 5 or 8 minutes or so. In TD games I prefer introducing different kinds of enemies one by one and explaining their weaknesses and streghts... here I got everything altogether, so I felt confused and stressed. Maybe it is described in the tutorial but since I do not know Spanish...
3) Music/sound starts automatically and I didn't need to change any settings, it was all ok.
4) I tried 3 times.
M.